Centrifugal Deposition of Microgels for the Rapid Assembly of Nonfouling Thin Films

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Thin films assembled from microgel building blocks have been constructed using a simple, high-throughput, and reproducible centrifugation (or "active") deposition technique. When compared to a common passive adsorption method (e.g., dip coating), microgels that are actively deposited onto a surface have smaller footprints and are more closely packed. Under both active and passive deposition conditions, the microgel footprint areas decrease during deposition. However, under active deposition, the microgel footprint appears to decrease continually and to a greater degree over the course of the deposition, forming a tightly packed, homogeneous him. Taking advantage of the rapid and uniform assembly of these films, we demonstrate the use of active deposition toward the fabrication of polyelectrolyte multilayers containing anionic microgels and a cationic linear polymer. Microgel multilayers successfully demonstrated effective blocking of the underlying substrate toward macrophage adhesion, which is a highly sought-after property for modulating the inflammatory response to an implanted biomaterial.


This is a pre-copy-editing, author-produced PDF of an article accepted for publication in ACS Applied Materials & Interfaces, volume 1,issue 12, 2009 following peer review. The definitive publisher-authenticated version is available online at DOI: 10.1021/am9005435.


American Chemical Society