Cooperative Melting in Caged Dimers with Only Two DNA Duplexes
Small molecule−DNA hybrids with only two parallel DNA duplexes (rSMDH2) displayed sharper melting profiles compared to unmodified DNA duplexes, consistent with predictions from neighboring-duplex theory. Using adjusted thermodynamic parameters obtained from a coarse-grain dynamic simulation, the experimental data fit well to an analytical model.
Eryazici, I.; Prytkova, T. R.; Schatz, G. C.; Nguyen, S. T. Cooperative melting in caged dimers with only two DNA duplexes. Journal of the American Chemical Society. 2010, 132.48, 17068-17070. doi: 0.1021/ja107232x
American Chemical Society
This is a pre-copy-editing, author-produced PDF of an article accepted for publication in journal of the American Chemical Society, volume 132, issue 48, in 2010 following peer review. The definitive publisher-authenticated version is available online at DOI: 0.1021/ja107232x.