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The opioid crisis in the United States has grown at an alarming rate. Children with cancer are at high risk for pain, and opioids are a first‐line treatment in this population. Accordingly, there is an urgent need to optimize pain management in children with cancer without contributing to the opioid crisis. This report details opportunities for this optimization, including clinical practice guidelines, comprehensive approaches to pain management, mobile health, and telemedicine. It is vital to balance appropriate use of analgesics with efforts to prevent misuse in order to reduce unnecessary suffering and minimize unintended harms.


This is the accepted version of the following article:

Fortier, MA, Yang, S, Phan, MT, Tomaszewski, DM, Jenkins, BN, Kain, ZN. Children's cancer pain in a world of the opioid epidemic: challenges and opportunities. Pediatr Blood Cancer. 2020; 67:e28124.

which has been published in final form at This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving.





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