Document Type


Publication Date




The goal of this study was to examine pain responses in pediatric patients with cancer.


Children (ages 6 to 18) undergoing treatment for cancer (N=68) completed the cold pressor task.


Average pain tolerance was 118.22 seconds (SD=101.18) and 40% of the children kept their hand in the water the entire 4-minute ceiling. On a 0 to 10 numeric rating scale, children reported a pain severity of 5.07 (SD=3.47) at their first report of pain, a pain severity of 5.94 (SD=3.54) at their maximum report of pain, and a pain severity of 5.33 (SD=3.72) at the time they reached pain tolerance. Children receiving chemotherapy agents (N=56) with possible neuropathic effects exhibited higher pain tolerance compared with children not receiving such treatments (N=10), β=0.84, SE=0.38, Wald χ21=4.88, P=0.027, hazard ratio=2.33, 95% confidence interval (1.10-4.92).


This study provides data on experimental pain responses in a sample of children undergoing cancer treatment and suggests that pain experience may be moderated by cancer treatment type.


This is a pre-copy-editing, author-produced PDF of an article accepted for publication in Journal of Pediatric Hematology/Oncology, volume 40, issue 5, in 2018 following peer review. The definitive publisher-authenticated version is available online at


Wolters Kluwer Health, Inc.



To view the content in your browser, please download Adobe Reader or, alternately,
you may Download the file to your hard drive.

NOTE: The latest versions of Adobe Reader do not support viewing PDF files within Firefox on Mac OS and if you are using a modern (Intel) Mac, there is no official plugin for viewing PDF files within the browser window.