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"Over their life time, CF patients experience multiple infections by various pneumoniacausing bacteria . With more patients surviving to adulthood, chronic infections with Pseudomonas aeruginosa are coming to the forefront as a leading cause of death . Problems presented by infected CF lung are multi-dimensional; the electrolyte balance and pH of the fluids are abnormal. The mucus is thick and of an alternative composition compared to normal lung and may contribute to colonization with Pseudomonas aeruginosa [2, 3, 5]. As such, research is multi-pronged and includes gene therapy to correct the defective protein, amelioration of inflammatory response and thinning of alveolar surface fluids [8, 9]. Significantly, Pseudomonas bacteria colonize the CF lung far easier than normal lung. Normal lung tissue has several naturally occurring defenses that work in concert with commonly prescribed antibiotics for recovery from lung infections [4, 10]. The CF patient appears to lack these natural defenses [1, 7]."
cystic fibrosis, lung disorders, Pseudomonas aeruginosa, pneumonia, multi-drug resistance, biolfilms
Bacteria | Bacterial Infections and Mycoses | Other Pharmacy and Pharmaceutical Sciences | Pharmaceutical Preparations | Pharmaceutics and Drug Design | Pharmacy and Pharmaceutical Sciences | Pulmonology | Respiratory Tract Diseases
Ayman M. Noreddin, Ghada Sawy, Walid Elkhatib, Ehab Noreddin and Atef Shibl (2012). Inhibition of Adhesion and Invasion of Pseudomonas aeruginosa to Lung Epithelial Cells: A Model of Cystic Fibrosis Infection, Lung Diseases - Selected State of the Art Reviews, Dr. Elvisegran Malcolm Irusen (Ed.), ISBN: 978-953-51-0180-2, InTech, Available from: http://www.intechopen.com/books/lung-diseases-selected-state-of-the-artreviews/ inhibition-of-adhesion-and-invasion-of-pseudomonas-aeruginosa-to-lung-epithelial-cells-a-model-of-cy
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