Cardiovascular complications are major causes of morbidity and mortality in patients with autosomal dominant polycystic kidney disease (ADPKD). In particular, hypertension is insidious and remains a continuous problem that evolves during the course of the disease. Hypertension in ADPKD has been associated with abnormality in the renin-angiotensin-aldosterone system (RAAS). Early vascular changes have also been reported in young ADPKD patients. In addition, the cellular functions of mechanosensory cilia within vascular system have emerged recently. The basic and clinical perspectives of RAAS, vascular remodeling and sensory cilia are reviewed with regard to hypertension in ADPKD
Ratnam S, Nauli SM. Hypertension in Autosomal Dominant Polycystic Kidney Disease: A Clinical and Basic Science Perspective. Int J Nephrol Urol. 2010; 2(2): 294-308.
Nephro and Urology Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran
Creative Commons License
This work is licensed under a Creative Commons Attribution-Noncommercial 4.0 License