Bi- and Tetracyclic Spirotetronates from the Coal Mine Fire Isolate Streptomyces sp. LC-6-2
The structures of 12 new “enantiomeric”-like abyssomicin metabolites (abyssomicins M–X) from Streptomyces sp. LC-6-2 are reported. Of this set, the abyssomicin W (11) contains an unprecedented 8/6/6/6 tetracyclic core, while the bicyclic abyssomicin X (12) represents the first reported naturally occurring linear spirotetronate. Metabolite structures were determined based on spectroscopic data and X-ray crystallography, and Streptomyces sp. LC-6-2 genome sequencing also revealed the corresponding putative biosynthetic gene cluster.
Wang X, Elshahawi SI, Cai W, et al. Bi- and tetracyclic spirotetronates from the coal mine fire isolate Streptomyces sp. LC-6-2. J Nat Prod. 2017;80(4):1141-1149. https://doi.org/10.1021/acs.jnatprod.7b00108
American Chemical Society and American Society of Pharmacognosy