Structure and Specificity of a Permissive Bacterial C-prenyltransferase
This study highlights the biochemical and structural characterization of the L-tryptophan C6 C-prenyltransferase (C-PT) PriB from Streptomyces sp. RM-5-8. PriB was found to be uniquely permissive to a diverse array of prenyl donors and acceptors including daptomycin. Two additional PTs also produced novel prenylated daptomycins with improved antibacterial activities over the parent drug.
Elshahawi SI, Cao C, Shaaban KA, et al. Structure and specificity of a permissive bacterial C-prenyltransferase. Nat. Chem Biol. 2017;13(4):366-368. https://doi.org/10.1038/nchembio.2285
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