Huisgen’s azide-alkyne cycloaddition reaction was employed to synthesize a series of 1H-1,2,3-triazole-tethered uracil-ferrocenyl chalcone conjugates with the aim of evaluating their in vitro anti-proliferative efficacy on human leukemia (CCRF-CEM) and human breast adenocarcinoma (MDA-MB-468) cell lines. Cytotoxic evaluation studies identified a number of synthesized conjugates that inhibited the proliferation of leukemia cancer cells by ~70% after 72 h. The selected synthesized conjugates were found to be significantly less cytotoxic against normal kidney cell line (LLC-PK1) when compared with CCRF-CEM cancer cells.
Singh A, Mehra V, Sadeghiani N, Mozaffari S, Parang K, Kumar V. Ferrocenylchalcone–uracil conjugates: Synthesis and cytotoxic evaluation. Med Chem Res. 2018;27(4):1260-1268. doi: 10.1007/s00044-018-2145-5
Available for download on Thursday, February 28, 2019
Biological Phenomena, Cell Phenomena, and Immunity Commons, Cancer Biology Commons, Chemical and Pharmacologic Phenomena Commons, Medical Biochemistry Commons, Medicinal-Pharmaceutical Chemistry Commons, Oncology Commons, Other Medicine and Health Sciences Commons