Document Type

Article

Publication Date

2-28-2018

Abstract

Huisgen’s azide-alkyne cycloaddition reaction was employed to synthesize a series of 1H-1,2,3-triazole-tethered uracil-ferrocenyl chalcone conjugates with the aim of evaluating their in vitro anti-proliferative efficacy on human leukemia (CCRF-CEM) and human breast adenocarcinoma (MDA-MB-468) cell lines. Cytotoxic evaluation studies identified a number of synthesized conjugates that inhibited the proliferation of leukemia cancer cells by ~70% after 72 h. The selected synthesized conjugates were found to be significantly less cytotoxic against normal kidney cell line (LLC-PK1) when compared with CCRF-CEM cancer cells.

Comments

This is a pre-copy-editing, author-produced PDF of an article accepted for publication in Medicinal Chemistry Research, volume 27, issue 4, in 2018 following peer review. The final publication is available at Springer via DOI:10.1007/s00044-018-2145-5.

Copyright

Springer

Available for download on Thursday, February 28, 2019

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