Hemoglobin E is a slow moving B chain variant of hemoglobin, first discovered by Itano1. Characterized by Hunt et al2 showed glutamic acid at B 26 to be replaced by lysine. It is a common variant of hemoglobin in the world and reported in high frequency from South-East Asia3-6. Cases of Hb E, in combination with thalassemia have been reported on the basis of electrophoretic pattern only. In this communication a case of Hb E with B thalassemia is reported on the basis of amino acid sequencing of the abnormal peptide.
Ahmed, A., A. Abbasi, G. Braunitzer, and Z.H. Zaidi. 1988. A case of Hb-E b-thalassemia in a Pakistani family. J. Pak. Med. Assoc. 38: 301-303.
Journal of Pakistan Medical Association