Hemoglobin E B-Thalassemia in a Pakistani Family

Authors

Aftab Ahmed, Chapman UniversityFollow
Atiya Abbasi, Max-Planck-Institut für Biochemie
Gerhard Braunitzer, Max-Planck-Institut für Biochemie
Zafar H. Zaidi, Univeristy of Karachi

Document Type

Article

Publication Date

1988

Abstract

Hemoglobin E is a slow moving B chain variant of hemoglobin, first discovered by Itano¹. Characterized by Hunt et al² showed glutamic acid at B 26 to be replaced by lysine. It is a common variant of hemoglobin in the world and reported in high frequency from South-East Asia^3-6. Cases of Hb E, in combination with thalassemia have been reported on the basis of electrophoretic pattern only. In this communication a case of Hb E with B thalassemia is reported on the basis of amino acid sequencing of the abnormal peptide.

Comments

This article was originally published in Journal of Pakistan Medical Association, volume 38, in 1988.

Recommended Citation

Ahmed, A., A. Abbasi, G. Braunitzer, and Z.H. Zaidi. 1988. A case of Hb-E b-thalassemia in a Pakistani family. J. Pak. Med. Assoc. 38: 301-303.

Copyright

Journal of Pakistan Medical Association