Cardiovascular complications are the most common cause of death in patients with polycystic kidney disease (PKD). Within the context of clinical practice, two possible theories have been reviewed that could help describe the pathogenesis of vascular complications in PKD (7).
Nauli SM. Editorial Focus: An ACE inhibitor improves vascular outcomes in a PKD model. Am J Physiol Renal Physiol. 2011 Nov;301(5):F958.
American Physiological Society