Date of Award

Summer 8-2021

Document Type


Degree Name

Master of Science (MS)


Pharmaceutical Sciences

First Advisor

Enrique Seoane-Vazquez

Second Advisor

Rosa Rodriguez-Monguio

Third Advisor

Lawrence M. Brown


Acute lymphoblastic leukemia (ALL) is a common type of adolescent and young adult leukemia in the United States (U.S.). Patients who are refractory or relapsed after receiving two or more lines of systemic therapy have the option of taking tisagenlecleucel. Due to the high cost of this treatment, a cost-effectiveness analysis was performed to assess the treatments for tisagenlecleucel, clofarabine combination, and blinatumomab. Objectives

The objective of this study is to evaluate the cost-effectiveness of tisagenlecleucel; clofarabine, etoposide, cyclophosphamide; and blinatumomab for the treatment of relapse- refractory ALL for adolescents and young adults from the U.S. health care payer perspective. Material and Methods

Clinical data were collected from the FDA databases, RedBook online, National Institutes of Health (NIH) research database, PubMed database, and The cost information was extracted from the Redbook and published studies. The cost-effective analysis was performed using TreeAge Pro (Healthcare Version) version 2021. Results

The incremental cost of tisagenlecleucel was $520,050 compared to blinatumomab. The base case showed tisagenlecleucel effectiveness was the highest at 19.284, and blinatumomab effectiveness was 12.580. Tisagenlecleucel had an ICER of $77,573. The probability sensitivity

Creative Commons License

Creative Commons License
This work is licensed under a Creative Commons Attribution-Noncommercial-No Derivative Works 4.0 License.



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