Student Scholar Symposium Abstracts and Posters

Document Type

Chapman access only poster or presentation

Publication Date

Spring 5-14-2015

Faculty Advisor(s)

Frank Frisch, Jason Keller


Osteoporosis, a disease in which porous holes develop in bone mineral causing decreased bone mineral density (BMD), presents a large risk to post-menopausal women, a population which according to the 2013 U.S. census maintains the highest demographic of females currently living in the U.S.. The increased prevalence of women in high powered careers in the recent decade calls to question the potential risks of sleep deprivation and stress to the health of women in such careers. To determine the effects of sleep deprivation (SD) and the effectiveness of Zoledrononate (Zol), a bisphosphonate drug which slows osteoclastic bone degradation, on BMD and TNF-a regulation, a cytokine previously linked to osteoclastic maturation, thirty-two sprague-dawley rats were chronically sleep deprived via a modified multiple platform method (MMPM) for a period of 6 weeks. SD*Zol were found to have a significant effect on TNF-a activity (p=0.003.) No effect of SD, Zol nor SD*Zol on BMD nor mineral gradient was observed. This observation was contrary to previous literature linking SD to decreased BMD. The inconstant findings likely exist as a result of two possible factors: minimal Zol uptake from pre-experimental Zol injection, and or, varied amount of physical activity and weight loading during SD and non-SD periods. We conclude that SD methods which allow for minimal physical activity will allow for clear examination of stress and sleep deprivation on BMD.


Presented at the Spring 2015 Student Research Day at Chapman University.

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