Dr. Allegra Liberman-Martin
The objective of this research is to discover an effective, safe, and low-cost catalyst for ketone hydrosilylation reactions, which involve the addition of a silicon–hydrogen bond across a C=O double bond. Improving catalyst efficiency could benefit the organic synthesis industry, as carbonyl hydrosilylation is used industrially in the synthesis of alcohol products. Use of the carbodiphosphorane catalyst as a replacement for toxic heavy-metal-containing catalysts could reduce waste and emissions harmful to the environment, while also providing an alternative means for accomplishing ketone reduction. Using a cyclic carbodiphosphorane catalyst, we have compared catalytic activity toward acetophenone hydrosilylation for a range of 18 silanes, the most effective of which was diphenylsilane. A range of 24 alkyl and aryl ketones have also been investigated. The carbodiphosphorane catalyst was more active in ketone hydrosilylation reactions compared to other nucleophilic organic catalysts tested.
Sullivan, Liam and Liberman-Martin, Allegra, "Ketone Hydrosilylation Studies Using a Carbodiphosphorane Catalyst" (2022). Student Scholar Symposium Abstracts and Posters. 537.