Chapman access only Poster
Dr. Allegra Liberman-Martin
Around 90% of all commercial chemicals require a catalyst for their production. However, many catalysts used in the refining, chemical, environmental, and polymer industries lead to harmful byproducts and deplete limited resources. An arising interest in carbodiphosphoranes (CDPs) supports the field of green chemistry by providing a more sustainable catalyst alternative while maintaining catalytic efficiency. Environmental concerns are mitigated when using carbodiphosphorane catalysts, which contain the main group element phosphorus as an earth abundant and inexpensive alternative to other industrial catalysts containing precious metals. This research investigates the use of a cyclic six-membered ring carbodiphosphorane with pinacolborane in catalyzing ketone hydroboration, a widely used reduction reaction in the pharmaceutical industry and production of consumer products. Carbodiphosphoranes contain a highly nucleophilic carbon center making them reactive Lewis bases and thus sensitive to air and moisture. Our research group utilizes a glovebox to maintain a nitrogen gas environment while working with these reactive compounds. This research seeks to uncover catalyst design principles to improve carbodiphosphorane reactivity. This presentation will discuss the carbodiphosphorane reactivity trends observed due to varying steric and electronic effects in the ketone substrates.
Fleener, Cara and Liberman-Martin, Allegra, "Ketone Hydroboration with a New Carbodiphosphorane Catalyst" (2021). Student Scholar Symposium Abstracts and Posters. 442.