The Warburg effect states that cancer cells mainly receive their energy from anaerobic glycolysis. Thus, mitochondria play a different role in the metabolism of cancer cells as opposed to normal, healthy cells. In chemotherapy, there is always a chance of the cancer regressing. Making drug-resistant cancer cells to analyze their metabolism may change how cancer is treated. This study aimed to create drug-resistant MCF-7 cell lines with doxorubicin in order to determine the metabolic changes that have occurred in the process of becoming resistant to drug treatments.
Han, Derick; Leung, Ho; and Vo, Andrew, "Analyzation of Metabolic Reprogramming in Drug-Resistant MCF-7 Cells" (2015). Student Research Day Abstracts and Posters. 168.