Field cancerization denotes the presence of molecular aberrations (genetic, epigenetic, biochemical) in structurally intact cells residing in histologically normal tissues adjacent to tumors. Markers of field cancerization in prostate tissues have the potential to improve the clinical management of this malignancy through their potential to act as indicators of early disease and to serve as molecular targets for early intervention. However, for this, a detailed understanding of the functional pathways underlying field cancerization is necessary. We have recently identified four protein markers of prostate field cancerization, i.e. the key transcription factor early growth response 1 (EGR-1), the lipogenic enzyme fatty acid synthase (FASN), and the secreted growth factors platelet derived growth factor A (PDGF-A) and macrophage inhibitory cytokine 1 (MIC-1). In this study, we provide for the first time a comprehensive association analysis between these factors, especially a potentially regulatory role of EGR-1 for the other factors, using cell models of prostate cancer and expression data in human prostate tissues. Our results indicate a potential discrepancy between research in vitro and observations in situ. More importantly, our detailed tissue expression analyses reveal novel functional pathways of prostate cancerization with a central regulatory role for EGR-1.
Gabriel, Kristin and Bisoffi, Marco, "Exploring EGR-1 as a Master Regulator of Prostate Field Cancerization" (2015). Student Scholar Symposium Abstracts and Posters. 137.