Chapman access only Poster
While 1.7 million Americans are hospitalized from Traumatic Brain Injury (TBI) each year, an even greater amount of Americans suffer from mild TBI (mTBI). There is mounting evidence that individuals experiencing repeated mTBI (rmTBI) can develop a unique pathological and clinical manifestation of disease, including depression, anxiety, memory loss, and aggression. To model rmTBI in the laboratory, we have developed a novel mouse model that mimics behavioral and pathological changes observed in the clinical setting. Specifically, our model shows chronic changes in activity, anxiety, learning and memory performance, as well as major white matter atrophy.
Tiefenthaler, Casey; Gold, Eric M.; Hoa, Daniel; Cummings, Brian J.; and Anderson, Aileen J., "Long-Term White Matter Pathology Following a Novel Model of Repeated Mild Traumatic Brain Injury" (2015). Student Scholar Symposium Abstracts and Posters. 116.