"Synthesis of Multifunctional Nanogels Using a Protected Macromonomer A" by Neetu Singh and L. Andrew Lyon
 

Document Type

Article

Publication Date

2008

Abstract

Nanoparticles possessing multiple functionalities provide synthetic handles for varied surface chemistries, making them useful for a range of applications such as biotargeting and drug delivery. However, the combination of interfering functionalities on the same particle is often challenging. We have employed a synthetic scheme involving chemical protection/deprotection to combine interfering functional groups on the same hydrogel nanoparticle. The synthesis of amine-containing poly(N-isopropylacrylamide) nanogels was carried out via free radical precipitation polymerization by incorporating a Fmoc-protected amine poly(ethylene glycol) (PEG) macromonomer. The Fmoc group was then removed to obtain free amines, which were shown to be available for conjugation. We further explored pNIPAm-co-acrylic acid nanogels with a protected amine-PEG, yielding zwitterionic particles. With careful attention to the order of the chemoligation and deprotection steps, these interfering functional groups can be forced to behave in a pseudo-orthogonal fashion, allowing for multiple chemoligation steps that employ both the amine and carboxylic acid groups.

Comments

This is a pre-copy-editing, author-produced PDF of an article accepted for publication in Colloid and Polymer Science, volume 286, issue 8-9, in 2008 following peer review. The final publication is available at Springer DOI: 10.1007/s00396-008-1883-1.

Copyright

Springer

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