Title

Cooperative Melting in Caged Dimers with Only Two DNA Duplexes

Document Type

Article

Publication Date

2010

Abstract

Small molecule−DNA hybrids with only two parallel DNA duplexes (rSMDH2) displayed sharper melting profiles compared to unmodified DNA duplexes, consistent with predictions from neighboring-duplex theory. Using adjusted thermodynamic parameters obtained from a coarse-grain dynamic simulation, the experimental data fit well to an analytical model.

Comments

This is a pre-copy-editing, author-produced PDF of an article accepted for publication in journal of the American Chemical Society, volume 132, issue 48, in 2010 following peer review. The definitive publisher-authenticated version is available online at DOI: 0.1021/ja107232x.

Copyright

American Chemical Society