Cooperative Melting in Caged Dimers with Only Two DNA Duplexes

Authors

Ibrahim Eryazici, Northwestern University
Tatiana Prytkova, Chapman UniversityFollow
George C. Schatz, Northwestern University
SonBinh T. Nguyen, Northwestern University

Document Type

Article

Publication Date

2010

Abstract

Small molecule−DNA hybrids with only two parallel DNA duplexes (rSMDH2) displayed sharper melting profiles compared to unmodified DNA duplexes, consistent with predictions from neighboring-duplex theory. Using adjusted thermodynamic parameters obtained from a coarse-grain dynamic simulation, the experimental data fit well to an analytical model.

Comments

This is a pre-copy-editing, author-produced PDF of an article accepted for publication in journal of the American Chemical Society, volume 132, issue 48, in 2010 following peer review. The definitive publisher-authenticated version is available online at DOI: 0.1021/ja107232x.

Recommended Citation

Eryazici, I.; Prytkova, T. R.; Schatz, G. C.; Nguyen, S. T. Cooperative melting in caged dimers with only two DNA duplexes. Journal of the American Chemical Society. 2010, 132.48, 17068-17070. doi: 0.1021/ja107232x

Copyright

American Chemical Society