Document Type
Article
Publication Date
12-25-2021
Abstract
Ciliary extracellular vesicles (ciEVs), released from primary cilia, contain functional proteins that play an important role in cilia structure and functions. We have recently shown that ciEVs and cytosolic extracellular vesicles (cyEVs) have unique and distinct biomarkers. While ciEV biomarkers have shown some interactions with known ciliary proteins, little is known about the interaction of ciEV proteins with proteins involved in ciliopathy and neurodegenerative disorders. Here, we reveal for the first time the protein-protein interaction (PPI) between the top five ciEVs biomarkers with ciliopathy and Alzheimer disease (AD) proteins. These results support the growing evidence of the critical physiological roles of cilia in neurodegenerative disorders.
Recommended Citation
Mohieldin AM, Alachkar A, Yates J, Nauli SM. Novel biomarkers of ciliary extracellular vesicles interact with ciliopathy and Alzheimer’s associated proteins. Commun Integr Biol. 2021;14(1):264-269. https://doi.org/10.1080/19420889.2021.2017099
Copyright
The authors
Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 License.
Included in
Amino Acids, Peptides, and Proteins Commons, Cell Anatomy Commons, Cell Biology Commons, Medicinal and Pharmaceutical Chemistry Commons, Nervous System Diseases Commons, Other Pharmacy and Pharmaceutical Sciences Commons
Comments
This article was originally published in Communicative & Integrative Biology, volume 14, issue 1, in 2021. https://doi.org/10.1080/19420889.2021.2017099