Document Type
Article
Publication Date
2009
Abstract
The Human Cytomegalovirus (HCMV)-encoded chemokine receptor US28 is the most well-characterized of the four chemokine receptor-like molecules found in the HCMV genome. US28 been studied as an important virulence factor for HCMV-mediated vascular disease and, more recently, in models of HCMV-associated malignancy. US28 is a rare multi-chemokine family binding receptor with the ability to bind ligands from two distinct chemokine classes. Ligand binding to US28 activates cell-type and ligand-specific signaling pathways leading to cellular migration, an example receptor functional selectivity. Additionally, US28 has been demonstrated to constitutively activate PLC and NFkB. Understanding the structure/function relationships between US28, its ligands and intracellular signaling molecules will provide essential clues for effective pharmacological targeting this multifunctional chemokine receptor.
Recommended Citation
Vomaske J, Nelson JA, Streblow DN. Human cytomegalovirus US28: A functionally selective chemokine binding receptor. Infect Disord Drug Targets. 2009;9(5):548-556.
Copyright
Bentham Science Publishers
Included in
Amino Acids, Peptides, and Proteins Commons, Complex Mixtures Commons, Hemic and Immune Systems Commons, Other Pharmacy and Pharmaceutical Sciences Commons, Virus Diseases Commons
Comments
This is a pre-copy-editing, author-produced PDF of an article accepted for publication in Infectious Disorders - Drug Targets, volume, in year following peer review. This article may not exactly replicate the final published version.