Document Type
Article
Publication Date
8-19-2015
Abstract
Purpose. Antibiotics have revolutionized modern medicine, allowing significant progress in healthcare and improvement in life expectancy. Development of antibiotic resistance by pathogenic bacteria is a natural phenomenon; however, the rate of antibiotic resistance emergence is increasing at an alarming rate, due to indiscriminate use of antibiotics in healthcare, agriculture and even everyday products. Traditionally, antibiotic discovery has been conducted by screening extracts of microorganisms for antimicrobial activity. However, this conventional source has been over-used to such an extent that it poses the risk of “running out” of new antibiotics. Aiming to increase access to a greater diversity of microorganisms, a new cultivation method with an in situ approach called iChip has been designed. The iChip has already isolated many novel organisms, as well as Teixobactin, a novel antibiotic with significant potency against Gram-positive bacteria.
Recommended Citation
Sherpa, R.T., Reese, C.J., Aliabadi, H.M., 2015. Application of iChip to Grow “Uncultivable” Microorganisms and its Impact on Antibiotic Discovery. Journal of Pharmacy & Pharmaceutical Sciences 18, 303–315.
Creative Commons License
This work is licensed under a Creative Commons Attribution-Share Alike 4.0 License.
Included in
Bacteria Commons, Other Chemicals and Drugs Commons, Pharmaceutical Preparations Commons, Pharmaceutics and Drug Design Commons
Comments
This article was originally published in Journal of Pharmacy & Pharmaceutical Sciences, volume 18, in 2015.