The Mechanosensory Role of Primary Cilia in Vascular Hypertension

Authors

Surya M. Nauli, Chapman UniversityFollow
Xingjian Jin, University of Toledo
Beerend P. Hierck, University of ToledoFollow

Document Type

Article

Publication Date

2011

Abstract

Local regulation of vascular tone plays an important role in cardiovascular control of blood pressure. Aside from chemical or hormonal regulations, this local homeostasis is highly regulated by fluid-shear stress. It was previously unclear how vascular endothelial cells were able to sense fluid-shear stress. The cellular functions of mechanosensory cilia within vascular system have emerged recently. In particular, hypertension is insidious and remains a continuous problem that evolves during the course of polycystic kidney disease (PKD). The basic and clinical perspectives on primary cilia are discussed with regard to the pathogenesis of hypertension in PKD.

Comments

This article was originally published in International Journal of Vascular Medicine in 2011. DOI: 10.1155/2011/376281

Recommended Citation

Nauli SM, Jin X, Hierck BP. The mechanosensory role of primary cilia in vascular hypertension. Int J Vasc Med. 2011;2011:376281.
DOI: 10.1155/2011/376281

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 License.