The Roles of Primary Cilia in Polycystic Kidney Disease

Authors

Samred H. Kathem, Chapman UniversityFollow
Ashraf M. Mohieldin, University of Toledo
Surya M. Nauli, Chapman UniversityFollow

Document Type

Article

Publication Date

2013

Abstract

Autosomal dominant polycystic kidney disease (ADPKD) is an inherited genetic disorder that results in progressive renal cyst formation with ultimate loss of renal function and other systemic disorders. These systemic disorders include abnormalities in cardiovascular, portal, pancreatic and gastrointestinal systems. ADPKD is considered to be among the ciliopathy diseases due to the association with abnormal primary cilia function. In order to understand the full course of primary cilia and its association with ADPKD, the structure, functions and role of primary cilia have been meticulously investigated. As a result, the focus on primary cilia has emerged to support the vital roles of primary cilia in ADPKD. The primary cilia have been shown to have not only a mechanosensory function but also a chemosensory function. Both structural and functional defects in primary cilia result in cystic kidney disease and vascular hypertension. Thus, the mechanosenory and chemosensory functions will be analyzed in regards to ADPKD.

Comments

This article was originally published in AIMS Molecular Science, volume 1,in 2013. DOI: 10.3934/molsci.2013.1.27

Recommended Citation

Kathem SH, Mohieldin AM, Nauli SM. The Roles of Primary cilia in Polycystic Kidney Disease. AIMS Molecular Science. Volume 1, 2013, 27-46.
DOI: 10.3934/molsci.2013.1.27

Creative Commons License

This work is licensed under a Creative Commons Attribution 3.0 License.