Document Type
Article
Publication Date
2015
Abstract
Activation of dopamine receptor type-5 (DR5) has been known to reduce systemic blood pressure, most likely by increasing renal vasodilation and enhancing natriuresis in the kidney. However, the mechanism of DR5 in natriuresis and vasodilation was not clearly known. We have previously shown that DR5 is localized to primary cilia of proximal renal epithelial and vascular endothelial cells. We here show that selective activation of DR5 specifically induces calcium influx only in the primary cilia, whereas non-selective activation of dopamine receptor induces calcium fluxes in both cilioplasm and cytoplasm. Cilia-independent signaling induced by thrombin only shows calcium signaling within cytoplasm. Furthermore, calcium activation in the cilioplasm by DR5 increases length and mechanosensory function of primary cilia, leading to a greater response to fluid-shear stress. We therefore propose a new mechanism by which DR5 induces vasodilation via chemical and mechanical properties that are specific to primary cilia.
Recommended Citation
Atkinson KF, Kathem S, Jin X, Muntean BS, Abou-alaiwi W, Nauli A and Nauli S(2015) Dopaminergic signaling within the primary cilia in the renovascular system. Front. Physiol. 6:103. doi:10.3389/fphys.2015.00103
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The authors
Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 License.
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Cardiovascular Diseases Commons, Cardiovascular System Commons, Cell Anatomy Commons, Cell Biology Commons, Endocrine System Commons, Endocrine System Diseases Commons
Comments
This article was originally published inFrontiers in Physiology, volume 6, issue 103, in 2015.DOI: 10.3389/fphys.2015.00103
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