Estimation of Pharmacokinetic Parameters Based on the Patient-Adjusted Population Data
Document Type
Article
Publication Date
2006
Abstract
Population pharmacokinetic data, adjusted for patient characteristics, are recommended for the design of initial dosage regimens of some therapeutically monitored drugs in patients for whom patient-specific data are not available. However, despite widespread use by clinicians such as pharmacists, a clear understanding of the principles of population pharmacokinetics, including data collection and analysis and its limitations, is often lacking. This article describes the 2 main methods of obtaining population kinetic data, namely the two-stage method and nonlinear mixed effect model, and their applications to the pharmacokinetic-based design of dosage regimens. Additionally, some numerical examples are provided to assist the reader in understanding the material. The author uses these tools in a pharmacokinetics course taught to PharmD students.
Recommended Citation
Mehvar, Reza. "Estimation of pharmacokinetic parameters based on the patient-adjusted population data." American journal of pharmaceutical education 70.5 (2006).
Copyright
American Association of Colleges of Pharmacy
Comments
This article was originally published in American Journal of Pharmaceutical Education, volume 70, issue 5, in 2006.