Analyzation of Metabolic Reprogramming in Drug-Resistant MCF-7 Cells

Authors

Derick Han, Keck Graduate InstituteFollow
Ho Leung, Keck Graudate InstituteFollow
Andrew Vo, Chapman UniversityFollow

Document Type

Poster

Publication Date

Spring 5-14-2015

Faculty Advisor(s)

Melissa Rowland-Goldsmith

Abstract

The Warburg effect states that cancer cells mainly receive their energy from anaerobic glycolysis. Thus, mitochondria play a different role in the metabolism of cancer cells as opposed to normal, healthy cells. In chemotherapy, there is always a chance of the cancer regressing. Making drug-resistant cancer cells to analyze their metabolism may change how cancer is treated. This study aimed to create drug-resistant MCF-7 cell lines with doxorubicin in order to determine the metabolic changes that have occurred in the process of becoming resistant to drug treatments.

Comments

Presented at the Spring 2015 Student Research Day at Chapman University.

Recommended Citation

Han, Derick; Leung, Ho; and Vo, Andrew, "Analyzation of Metabolic Reprogramming in Drug-Resistant MCF-7 Cells" (2015). Student Scholar Symposium Abstracts and Posters. 168.
https://digitalcommons.chapman.edu/cusrd_abstracts/168