Student Scholar Symposium Abstracts and Posters
Document Type
Poster
Publication Date
Spring 5-14-2015
Faculty Advisor(s)
Marco Bisoffi
Abstract
Analysis of tumor adjacent tissue is assumed to reveal a temporal record of molecular pathways that define oncogenesis. The present study determines expression of the key transcription factor and potential marker of field cancerization early growth response 1 (EGR-1) in human prostate tissues derived from prostatectomies and biopsies. Expression was detected using immunofluorescence and quantified using ImageJ software. Accordingly, EGR-1 expression was similar in cancerous and in histologically normal adjacent tissues from prostatectomy and biopsy specimens. EGR-1 could be exploited as pre-surgical disease indicator in false negative biopsies, identify areas of repeat biopsy, and add molecular information to surgical margins.
Recommended Citation
Shoshan, Dor, "Prostate Field Cancerization – Thinking Outside the Tumor" (2015). Student Scholar Symposium Abstracts and Posters. 159.
https://digitalcommons.chapman.edu/cusrd_abstracts/159
Comments
Presented at the Spring 2015 Student Research Day at Chapman University.