Long-Term White Matter Pathology Following a Novel Model of Repeated Mild Traumatic Brain Injury

Authors

Casey Tiefenthaler, Chapman UniversityFollow
Eric M. Gold, University of California - Irvine
Daniel Hoa, University of California - Irvine
Brian J. Cummings, University of California - Irvine
Aileen J. Anderson, University of California - Irvine

Document Type

Chapman access only poster or presentation

Publication Date

Spring 5-14-2015

Faculty Advisor(s)

Melissa Rowland-Goldsmith

Abstract

While 1.7 million Americans are hospitalized from Traumatic Brain Injury (TBI) each year, an even greater amount of Americans suffer from mild TBI (mTBI). There is mounting evidence that individuals experiencing repeated mTBI (rmTBI) can develop a unique pathological and clinical manifestation of disease, including depression, anxiety, memory loss, and aggression. To model rmTBI in the laboratory, we have developed a novel mouse model that mimics behavioral and pathological changes observed in the clinical setting. Specifically, our model shows chronic changes in activity, anxiety, learning and memory performance, as well as major white matter atrophy.

Comments

Presented at the Spring 2015 Student Research Day at Chapman University.

Access to this poster is restricted to Chapman University students, faculty, staff, and affiliates.

Recommended Citation

Tiefenthaler, Casey; Gold, Eric M.; Hoa, Daniel; Cummings, Brian J.; and Anderson, Aileen J., "Long-Term White Matter Pathology Following a Novel Model of Repeated Mild Traumatic Brain Injury" (2015). Student Scholar Symposium Abstracts and Posters. 116.
https://digitalcommons.chapman.edu/cusrd_abstracts/116