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We demonstrate the utility of microgel core/shell structures conjugated to fibrin-specific peptides as fibrinolytic agents. Poly(N-isopropylmethacrylamide) (pNIPMAm) based microgels conjugated to the peptide GPRPFPAC (GPRP) were observed to bring about fibrin clot erosion, merely through exploitation of the dynamic nature of the clots. These results suggest the potential utility of peptide–microgel hybrids in clot disruption and clotting modulation.


This is a pre-copy-editing, author-produced PDF of an article accepted for publication in Biomaterials Science in 2018 following peer review. The definitive publisher-authenticated version is available online at DOI: 10.1039/C8BM00119G.


Royal Society of Chemistry



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