New Perspectives on Melanoma Pathogenesis and Chemoprevention

Authors

Frank L. Meyskens Jr., University of California, Irvine
Patrick J. Farmer, University of California, Irvine
Sun Yang, Chapman UniversityFollow
Hoda Anton-Culver, University of California, Irvine

Files

Description

Epidemiologic studies implicate ultraviolet radiation (sunlight) as an etiologic agent for the pathogenesis of melanoma. However, the experimental evidence is less convincing. We present information from recent experimental findings that elevation of reactive oxygen species follows from melanin serving as a redox generator, and that this may play an important role in the etiology and pathogenesis of cutaneous melanoma. These observations offer a new paradigm for the development of preventive (and therapeutic) approaches to this disease.

ISBN

9783540376958

Publication Date

2007

Publisher

Springer

City

Berlin

Disciplines

Cancer Biology | Cell Biology | Medicinal and Pharmaceutical Chemistry | Oncology | Other Pharmacy and Pharmaceutical Sciences

Comments

In H.-J. Senn and U. Kapp (Eds.), Cancer Prevention, volume 174 of the Recent Results in Cancer Research series.

Recommended Citation

Meyskens FL, Farmer PJ, Yang S, Anton-Culver H. New perspectives on melanoma pathogenesis and chemoprevention. In: Senn HJ, Kapp U, eds. Cancer Prevention. Berlin: Springer; 2007: 191 - 195. Recent Results in Cancer Research Series; No. 174.

Copyright

Springer