Hemoglobin Karachi is a new a chain Variant with amino acid substitution a 5 (A3) Ala-“ Pro. The hematological data on the propositus were normal. In cellulose acetateelectro phoresis this hemoglobin migrated towards the anode slower than HbA.
It is the first a-chain abnormal hemoglobin reported from Pakistani population (JPMA 36:206, 1986).
Ahmed, A., S. Naqvi, S., S. Ehasanullah, and Z.H. Zaidi. 1986. Abnormal hemoglobin11 - Hb (Karachi), An a-Chain Abnormality at Position 5 Ala Pro. J. Pak. Med. Assoc. 36: 206-208.
Journal of Pakistan Medical Association