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Hemoglobin Karachi is a new a chain Variant with amino acid substitution a 5 (A3) Ala-“ Pro. The hematological data on the propositus were normal. In cellulose acetateelectro phoresis this hemoglobin migrated towards the anode slower than HbA.

It is the first a-chain abnormal hemoglobin reported from Pakistani population (JPMA 36:206, 1986).


This article was originally published in Journal of Pakistan Medical Association, volume 36, in 1986.


Journal of Pakistan Medical Association



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