siRNA Drug Delivery Across the Blood–Brain Barrier in Alzheimer's Disease

Authors

Muhammad Imran Sajid, Chapman UniversityFollow
Fahad Sultan Sheikh, Shifa Tameer-e-Millat University
Faiza Anis, Federal Urdu University of Arts, Science and Technology
Nourina Nasim, Lahore University of Management Sciences
Rachita K. Sumbria, Chapman UniversityFollow
Surya M. Nauli, Chapman UniversityFollow
Rakesh K. Tiwari, Chapman UniversityFollow

Document Type

Article

Publication Date

6-21-2023

Abstract

Alzheimer’s disease (AD) is a progressive neurodegenerative disease with a few FDA-approved drugs that provide modest symptomatic benefits and only two FDA-approved disease-modifying treatments for AD. The advancements in understanding the causative genes and non-coding sequences at the molecular level of the pathophysiology of AD have resulted in several exciting research papers that employed small interfering RNA (siRNA)-based therapy. Although siRNA is being sought by academia and biopharma industries, several challenges still need to be addressed. We comprehensively report the latest advances in AD pathophysiology, druggable targets, ongoing clinical trials, and the siRNA-based approaches across the blood–brain barrier for addressing AD. This review describes the latest delivery systems employed to address this barrier. Critical insights and future perspectives on siRNA therapy for AD are also provided.

Comments

NOTICE: this is the author’s version of a work that was accepted for publication in Advanced Drug Delivery Reviews. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in Advanced Drug Delivery Reviews, volume 199, in 2023. https://doi.org/10.1016/j.addr.2023.114968

The Creative Commons license below applies only to this version of the article.

Recommended Citation

Imran Sajid M, Sultan Sheikh F, Anis F, et al. siRNA drug delivery across the blood-brain barrier in Alzheimer's disease. Adv Drug Deliv Rev. 2023;199:114968. https://doi.org/10.1016/j.addr.2023.114968

Copyright

Elsevier

Creative Commons License

This work is licensed under a Creative Commons Attribution-Noncommercial-No Derivative Works 4.0 License.