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Estimation of pharmacokinetic parameters after intermittent intravenous infusion (III) of antibiotics, such as aminoglycosides or vancomycin, has traditionally been a difficult subject for students in clinical pharmacology or pharmacokinetic courses. Additionally, samples taken at different intervals during repeated dose therapy require manipulation of sampling times before accurate calculation of the patient-specific pharmacokinetic parameters. The main goal of this study was to evaluate the effectiveness of active learning tools and practice opportunities on the ability of students to estimate pharmacokinetic parameters from the plasma samples obtained at different intervals following intermittent intravenous infusion.


This article was originally published in BMC Medical Education, volume 12, issue 1, in 2012.DOI: 10.1186/1472-6920-12-116

This is an Open Access article distributed under the terms of the Creative Commons Attribution License 2.0 (, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


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