Title

Using DNA to Link Gold Nanoparticles, Polymers and Molecules: a Theoretical Perspective

Document Type

Article

Publication Date

2010

Abstract

This Perspective describes theoretical studies aimed at understanding the structural and thermal properties of materials in which DNA is used to link gold nanoparticles, or polymers or organic molecules. Particularly in the case of gold nanoparticles, the materials derived from this structural motif have proven to be important for biological sensing and other applications, however additional applications may arise as a result of recent advances in the preparation of crystalline materials based on DNA-linked particles. From a theory perspective these are challenging materials to describe due to the large number of atoms, and the polyelectrolyte character of DNA, however there has been important progress recently using all-atom and coarse-grained molecular dynamics, and with analytical theory. Among topics that we discuss are the structure and density of DNA when attached to gold particles, and the size and melting properties of DNA-linked nanoparticles in different environments.

Comments

This is a pre-copy-editing, author-produced PDF of an article accepted for publication in The Journal of Physical Chemistry Letters, volume 1, issue 12, in 2010 following peer review. The definitive publisher-authenticated version is available online at DOI: 10.1021/jz100435a .

Copyright

American Chemical Society