Document Type
Article
Publication Date
2003
Abstract
An imbalance between excitation and inhibition can play an important role in the generation of epileptiform activity. Experimental evidence indicates that alterations of either synaptic activity or intrinsic membrane properties may contribute to this imbalance. The slow Ca2+ - activated K+ currents (sIAHP) limit neuronal firing rate and excitability and are therefore of great interest for their potential role in epileptogenesis. The sIAHP is found in both excitatory and inhibitory neurons, and its effect on these neurons can influence the network behavior. Simulations show that the increased excitability caused by reduction of inhibition by the sIAHP for inhibitory interneuron generates recurrent bursting activity.
Recommended Citation
Yang, Keun-Hang, Piotr J. Franaszczuk, and Gregory K. Bergey. "The Influence of Slow Calcium-Activated Potassium Channels on Epileptiform Activity in a Neuronal Model of Pyramidal Cells." Computational Neuroscience Meeting (2003).
Peer Reviewed
1
Copyright
TNB
Comments
This is a pre-copy-editing, author-produced PDF of an article accepted for publication in the proceedings for the Computational Neuroscience Meeting in 2003.