Document Type

Article

Publication Date

6-13-2011

Abstract

Staphylococcus aureus strains (n = 50) causing complicated skin and skin structure infections produced various levels of phenol-soluble modulin alpha-type (PSMα) peptides; some produced more than twice that produced by the control strain (LAC USA300). TR-700 (oxazolidinone) and clindamycin strongly inhibited PSM production at one-half the MIC but exhibited weak to modest induction at one-fourth and one-eighth the MICs, primarily in low producers. Adequate dosing of these agents is emphasized to minimize the potential for paradoxical induction of virulence.

Comments

This article was originally published in Antimicrobial Agents and Chemotherapy, volume 55, issue 9, in 2011. DOI: 10.1128/AAC.00122-11

Copyright

American Society for Microbiology

 
 

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