Caveolin-2

Document Type

Article

Publication Date

2006

Abstract

Caveolin-2 may act as a scaffolding protein within caveolar/lipid raft membranes. Caveolin-2 forms stable hetero-oligomeric complexes with caveolin-1 in many cell types, including fibroblastic cells. Caveolin-2 can also interact with caveolin-3, the striated muscle-specific isoform, when co-expressed in muscle cells. Caveolin-2/caveolin-3 interaction does not occur in non-muscle cells. Caveolin-2 appears to act in conjunction with other caveolin isoforms to form the caveolar coat. The exact function of caveolin-2 in such hetero-oligomers in unknown.

Comments

This article was originally published in Alliance for Cell Signaling - Nature Molecule Pages in 2006. DOI: 10.1038/mp.a000521.01

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