Synthesis of Novel Ciprofloxacin Analogues and Evaluation of Their Anti-Proliferative Effect on Human Cancer Cell Lines

Authors

Narva Suresh, Birla Institute of Technology & Science
Hunsur Nagendra Nagesh, Birla Institute of Technology & Science
Kondapalli Venkata Govri Chandra Sekhar, Birla Institute of Technology & Science
Anil Kumar, Birla Institute of Technology & Science
Amir Nasrolahi Shirazi, Chapman UniversityFollow
Keykavous Parang, Chapman UniversityFollow

Document Type

Article

Publication Date

12-1-2013

Abstract

A series of twenty two novel 1-cyclopropyl-6-fluoro-4-oxo-7-(4-substitutedpiperazin-1-yl)-1,4-dihydroquinoline-3-carboxylic acid analogues have been synthesized, characterized (1H NMR, 13C NMR and LCMS) and evaluated for their inhibitory activity on the proliferation of human caucasian acute lymphoblastic leukemiacells (CCRF-CEM), breast adenocarcinoma cells (MDA-MB-468) and human colon carcinoma cells (HCT-116). Among all the synthesized ciprofloxacin analogues 3t at 50 µM showed comparable potency to doxorubicin (10mol) in all three cell lines and 3j inhibited proliferation of MDA-MB-468 up to 35% selectively over other two cell lines. Cancer is a leading cause of death worldwide. It is a group of diseases characterized by uncontrolled growth. Cancer is the second cause of death in the US

Comments

NOTICE: this is the author’s version of a work that was accepted for publication in Bioorganic & Medicinal Chemistry Letters. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in Bioorganic & Medicinal Chemistry Letters, volume 23, in 2013. DOI: 10.1016/j.bmcl.2013.09.077

The Creative Commons license below applies only to this version of the article.

Recommended Citation

Suresh N, Nagesh HN, Sekhar KVGC, Kumar A, Shirazi AN, Parang K. Synthesis of novel ciprofloxacin analogues and evaluation of their anti-proliferative effect on human cancer cell lines. Bioorg. Med. Chem. Lett. (2013);23:6292-6295. doi: 10.1016/j.bmcl.2013.09.077

Copyright

Elsevier

Creative Commons License

This work is licensed under a Creative Commons Attribution-Noncommercial-No Derivative Works 4.0 License.